PreciS™-G Blood Glucose Monitoring System (Professional Use)

Diabetes mellitus is a chronic condition that occurs when the pancreas does not produce enough insulin, or when the body is unable to use insulin effectively.

Insulin is the hormone that regulates the transfer of glucose (sugar) from the bloodstream into body cells, where it is used for energy. Without sufficient insulin action, blood sugar levels rise, leading to hyperglycemia, or high blood glucose.

Persistently high blood glucose can lead to serious and long-term complications. For example, people with diabetes are two to four times more likely to develop coronary artery disease and stroke. This increased risk is often linked to other cardiovascular risk factors, such as high blood pressure, high cholesterol, and obesity.

Management of diabetes goes beyond controlling blood glucose levels, optimizing cholesterol, blood pressure, weight and lifestyle go a long way in minimising the risk of future complications.

PreciSTM – C Cholesterol Monitoring System uses a timed-endpoint method to measure the Total Cholesterol (CHOL), High Density Lipoprotein (HDL) and Triglyceride (TRIG) concentrations in whole blood, serum or plasma. The concentration of Low Density Lipoprotein (LDL) is calculated by the values of CHOL, TRIG and HDL. The system monitors the change in light absorbance at a fixed time interval. The change in absorbance is directly proportional to the concentration of lipid in the specimen.

CHOL: In this reaction, a cholesterol specific enzyme hydrolyzes cholesterol esters to free cholesterol and fatty acids. The free cholesterol is oxidized to cholestene-3-one and hydrogen peroxide by another enzyme. Hydrogen peroxide and a substrate is then further catalyzed by a 3rd enzyme to produce a coloured product.

HDL: HDL in the specimen is separated (from chylomicrons, VLDL and LDL) within the test device and then determined enzymatically as CHOL.

TRIG: Triglycerides in the specimen are enzymatically hydrolyzed to glycerol and free fatty acids. Next, a sequence of three coupled enzymatic steps causes the oxidation of a substrate to form a coloured product.

LDL: LDL is calculated when the concentration of TRIG in the specimen is equal or lower than 400 mg/dL. The following equation is use: CHOL – HDL – TRIG/2.2 (mmol/L) or CHOL – HDL – TRIG/5 (mg/dL)